Table 4 Multinomial logistic analysis of frequency of coughing by age group, gender and mutation group
From: Prevalence and onset of comorbidities in the CDKL5 disorder differ from Rett syndrome
| Â | Do not occur | Sometimes occur | Often occur | ||||
|---|---|---|---|---|---|---|---|
|  | (n = 25) | (n = 47) | (n = 21) | ||||
| Â | n (%) | n (%) | RRR (95Â % CI) | p value | n (%) | RRR (95Â % CI) | p value |
Age group | Â | Â | Â | Â | Â | Â | Â |
 0 to <5 years | 7 (28.0) | 24 (54.6) | – | – | 13 (61.9) | – | – |
 5 to <10 years | 10 (40.0) | 13 (46.4) | 0.26 (0.07,1.01) | 0.05 | 5 (23.8) | 0.13 (0.02,0.73) | 0.02 |
 10 years or older | 8 (32.0) | 11 (22.9) | 0.25 (0.06,0.98) | 0.05 | 3 (14.3) | 0.16 (0.03,0.91) | 0.04 |
Gender | Â | Â | Â | Â | Â | Â | Â |
 Female | 23 (92.0) | 44 (91.7) | – | – | 19 (90.5) | – |  |
 Male | 2 (8.0) | 4 (8.3) | 1.83 (0.17,20.20) | 0.62 | 2 (9.5) | 0.80 (0.04,16.47) | 0.88 |
Mutation group | Â | Â | Â | Â | Â | Â | Â |
 No functional protein | 8 (32.0) | 15 (31.9) | – | – | – | – | – |
 Missense/in-frame mutation within catalytic domain | 6 (24.0) | 12 (25.5) | 1.05 (0.26,4.32) | 0.94 | 6 (28.6) | 1.32 (0.25,7.13) | 0.74 |
 Truncation between aa172 and aa781 | 6 (24.0) | 12 (25.5) | 1.30 (0.31,5.48) | 0.72 | 4 (19.1) | 1.10 (0.18,6.67) | 0.92 |
 Truncation after aa781 | 2 (8.0) | 5 (10.6) | 1.23 (0.19,8.05) | 0.83 | 3 (14.3) | 2.36 (0.26,21.16) | 0.44 |