Table 5 Multivariate logistic analyses of any and specific current sleep problems by age, gender and mutation group
From: Prevalence and onset of comorbidities in the CDKL5 disorder differ from Rett syndrome
| Â | Any sleep problem | Night waking | Night screaming | Night laughing | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|  | (n = 122) | (n = 72) | (n = 29) | (n = 34) | ||||||||
| Â | n (%) | OR (95Â % CI) | p value | n (%) | OR (95Â % CI) | p value | n (%) | OR (95Â % CI) | p value | n (%) | OR (95Â % CI) | p value |
|  | N = 131 |  |  | N = 112 |  |  | N = 116 |  |  | N = 125 |  |  |
Age group | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 0 to <5 years | 53 (40.5) | baseline | – | 48 (42.9) | baseline | – | 47 (40.5) | baseline | – | 53 (42.4) | baseline | – |
 5 to < 10 years | 42 (32.1) | 13.09 (1.57,109.02) | 0.02 | 36(32.1) | 9.16 (2.91,28.86) | <0.001 | 38 (32.8) | 1.01 (0.34,3.02) | 0.98 | 40 (32.0) | 0.96 (0.32,2.92) | 0.95 |
 10 years or older | 36 (27.5) | 1.48 (0.45,4.84) | 0.52 | 28 (25.0) | 1.80 (0.67,4.85) | 0.24 | 31 (26.7) | 1.22 (0.41,3.67) | 0.72 | 32 (25.6) | 3.38 (1.20,9.53) | 0.02 |
Gender | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Female | 116 (88.6) | baseline | – | 98 (87.5) | baseline | – | 101 (87.1) | baseline | – | 107 (85.6) | baseline | – |
 Male | 15 (11.5) | 2.37 (0.27,20.53) | 0.43 | 14 (12.5) | 0.98 (0.27,3.53) | 0.98 | 15 (12.9) | 0.63 (0.16,2.53) | 0.52 | 18 (14.4) | 1.86 (0.38,4.05) | 0.33 |
Mutation group | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 No functional protein | 45 (34.4) | baseline | – | 39 (34.8) | baseline | – | 40 (34.5) | baseline | – | 40 (34.5) | baseline | – |
 Missense/in-frame mutation within catalytic domain | 40 (30.5) | 0.59 (0.14,2.49) | 0.48 | 33 (29.5) | 0.74 (0.26,2.12) | 0.58 | 35 (30.2) | 1.37 (0.50,3.78) | 0.54 | 35 (30.2) | 1.67 (0.58,4.78) | 0.34 |
 Truncation between aa172 and aa781 | 30 (22.9) | 0.32 (0.08,1.33) | 0.12 | 28 (25.0) | 0.32 (0.10,0.99) | 0.05 | 28 (24.1) | 0.19 (0.04,0.98) | 0.05 | 28 (24.1) | 0.87 (0.26,2.89) | 0.82 |
 Truncation after aa781 | 16 (12.2) | 0.41 (0.06,2.78) | 0.37 | 12 (10.7) | 0.24 (0.05,1.08) | 0.06 | 13 (11.2) | 0.48 (0.09,2.63) | 0.40 | 13 (11.2) | 0.22 (0.02,1.98) | 0.18 |