Table 1 Base case and sensitivity analysis by geographic area (sensitivity analysis includes only studies with birth prevalence estimates derived from newborn screening studies) (detection rate per 100,000 newborns)
From: Systematic literature review and meta-analysis on the epidemiology of propionic acidemia
Base case | Sensitivity analysis (birth prevalence) | |||||
|---|---|---|---|---|---|---|
Continent | point estimate (95% CI) | Number of studies | I2 | point estimate (95% CI) | Number of studies | I2 |
North America | 0.33 | 6 | 33.76% | 0.41 | 5 | 47.01% |
(0.11–0.63) | (0.09–0.89) | |||||
Europe | 0.33 | 10 | 23.83% | 0.41 | 8 | 15.42% |
(0.15–0.57) | (0.13–0.80) | |||||
Asia-Pacific | 0.29 | 10(12 cohorts) | 79.31% | 0.48 | 9 | 79.68% |
(0.03–0.74) | (0.04–1.24) | |||||
MENA | 4.24 | 5 | 48.71% | 4.48 | 3 | 28.73% |
(2.53–6.31) | (1.34–9.00) | |||||