Quality of life data for individuals affected by spinal muscular atrophy: a baseline dataset from the Cure SMA Community Update Survey

Table 4 WPAI Sub-scores Stratified by Caregiver and Affected Individual

Functional Status	Caregiver		Affected Adult		Overall		Significance testing^a
Functional Status	Mean (SD)	Sample Size	Mean (SD)	Sample Size	Mean (SD)	Sample Size	P value
Permanent Ventilation
Absenteeism, %	7.6 (9.1)	4	N/A	N/A	6.1 (8.6)	5	N/A
Presenteeism, %	76.4 (31.1)	11	N/A	N/A	73.1 (34.7)	13	N/A
Overall Impairment, %	59.0 (43.3)	4	N/A	N/A	49.2 (43.4)	5	N/A
Activity Impairment, %	83.1 (20.9)	35	68.8 (25.3)	8	80.5 (22.2)	43	0.13^b
Non-sitters
Absenteeism, %	13.3 (15.1)	16	6.4 (13.6)	15	10.0 (14.6)	31	0.09^b
Presenteeism, %	47.0 (31.8)	23	36.7 (29.5)	18	42.4 (30.9)	41	0.29
Overall Impairment, %	50.1 (27.3)	16	37.2 (28.8)	15	43.9 (28.3)	31	0.21
Activity Impairment, %	60.8 (29.4)	50	69.1 (21.5)	34	64.2 (26.7)	84	0.14
Sitters
Absenteeism, %	18.8 (29.0)	36	6.8 (12.1)	31	13.3 (23.4)	67	0.04*
Presenteeism, %	41.6 (31.0)	45	44.5 (30.1)	40	42.9 (30.5)	85	0.66
Overall Impairment, %	44.6 (29.6)	33	41.0 (23.7)	30	42.9 (26.8)	63	0.59
Activity Impairment, %	60.9 (25.2)	123	55.2 (22.6)	65	58.9 (24.4)	188	0.09^b
Walk with Support
Absenteeism, %	16.3 (11.5)	6	8.5 (11.8)	4	13.2 (11.6)	10	0.34
Presenteeism, %	55.0 (31.2)	8	50.0 (33.7)	4	53.3 (30.6)	12	0.93^b
Overall Impairment, %	62.7 (19.5)	6	53.2 (35.5)	4	58.9 (25.6)	10	0.59^b
Activity Impairment, %	50.0 (26.5)	27	7.0 (61.4)	7	52.4 (26.3)	34	0.22^b
Walk Independently
Absenteeism, %	4.4 (8.1)	6	6.8 (15.1)	12	6.0 (12.9)	18	0.91^b
Presenteeism, %	17.5 (22.5)	8	37.3 (25.5)	15	30.4 (25.8%)	23	0.07
Overall Impairment, %	25.5 (26.5)	6	35.5 (28.1)	12	32.2 (27.2)	18	0.40^b
Activity Impairment, %	41.2 (24.2)	25	55.0 (22.3)	26	48.2 (24.1)	51	0.02*^,b

^a Significance testing between work productivity of a caregiver and an affected adult
*Statistically significant at p < 0.05
^b Mann-Whitney test used to test for significance

ISSN: 1750-1172