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Table 2 Incidence of each inherited metabolic disease among Jews versus Bedouin-Muslim population, in southern of Israel, between the years 1990 and 2017

From: Incidence of inherited metabolic disorders in southern Israel: a comparison between consanguinity and non-consanguinity communities

Disease category Overall incidence/100,000 live births Incidence among Bedouin-Muslim/100,000 live births Incidence among Jews/100,000 live births P value
Aminoacidopathy     
Maple syrup urine disease (MSUD) 4.8 10.2 0 < 0.001
Non-ketotic hyperglycinemia 3.8 8 0 < 0.001
Peroxisomal diseases     
X-linked Adrenoleukodystrophy 0.8 0 1.6 0.1
Zellweger disease 4.6 8.2 0.5 < 0.001
Sphingolipidosis     
Niemann Pick C type 1 4.8 9.1 1 < 0.001
Organic aciduria     
Glutaric aciduria type 1 2 4.3 0 0.003
Fatty acid oxidation diseases     
Multiple acyl-CoA dehydrogenase deficiency 0.5 1 0 0.1
Medium chain acyl-CoA dehydrogenase deficiency 1 0.5 1.5 0.4
Very long chain acyl-CoA dehydrogenase deficiency 2.3 4.3 0.5 0.01
Carnitine palmitoyl-transferase 1A 0.3 0.5 0 0.3
Carnitine palmitoyl- transferase 2 0.5 0 1 0.2
Long chain 3-hydroxyl-CoA dehydrogenase deficiency 0.5 0.3 0 0.3
Mucopolysaccharidosis     
Mucopolysaccharidosis type 1 1 1.1 1 0.9
Mucopolysaccharidosis type 3 2 3.7 0.5 0.02
Mucopolysaccharidosis type 3 2.8 5.9 0 < 0.001
Unclassified mucopolysaccharidosis 0.8 1.1 0.5 0.6
Glycogen storage diseases     
Glycogen storage disease type 0 0.3 0 0.5 0.3
Glycogen storage disease type 1A 1.5 0 2.9 0.02
Glycogen Storage disease type 1B 4.1 8 0.5 < 0.001
Glycogen storage disease type IIIA 1.8 0 3.7 < 0.001
Glycogen storage disease type 6 2.3 4.8 0 < 0.001
Glycogen storage disease type 9 0.3 0.5 0 0.3
Glycogen storage disease type 11 0.3 0.5 0 0.3
Unclassified glycogen storage disease 0.8 1.1 0.5 0.6
Pompe disease (type 2 glycogen storage disease) 2.3 4.8 0 0.003
Mitochondrial diseases     
Complex 1 deficiency 2.8 5.9 0 < 0.001
Complex 3 deficiency 3.3 7 0 < 0.001
Complex 5 deficiency 1.8 3.7 0 0.005
Pyruvate dehydrogenase deficiency type 1A 0.3 0 0.5 0.3
Pyruvate dehydrogenase deficiency type E3 0.5 1.1 0 0.2
Kearns Sayre syndrome 0.3 0 0.5 0.3
Mitochondrial neuro-gastrointestinal encephalopathy disease 0.3 0.5 0 0.3
Trans-membrane protein 70 (TMEM70) deficiency 0.5 1.1 0 0.2
Mitochondrial DNA depletion 0.5 1.1 0 0.2
Unspecified mitochondrial disease 0.3 0.5 0 0.3