Fig. 1

Descriptive statistics of the study population. Age distribution of males (top) and females (bottom) at last follow-up (a); Breakdown of study population into cohorts based on source of data (b); Phenotypic variability within our study population (c). ^aClassic AMN defined as one or more of the following neurological signs and symptoms: gait disturbance, positive Romberg test, presence of foot drop, patient-reported frequent falls, use of one or more walking aids, or numbness/weakness/decreased vibration sensation in one or more extremities. We did not include patients presenting only with urinary and/or bowel symptom(s). ^bSelf-halted CALD defined as abnormal hyperintensity on brain MRI with no active gadolinium enhancement