Fig. 3
From: Bone fragility in patients affected by congenital diseases non skeletal in origin
Pathogenesis of thalassemia. α Thalassemia: mutations of the gene encoding for the α chain located on chromosome 16 (mainly deletions) induces an excess of β chains with the presence of inclusion bodies in the cells. β Thalassemia: mutations of the gene located on chromosome 11 that encodes for the β chains induces an excess of α chains with the presence of inclusion bodies in the cells