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Table 2 Uni- and multi-variate Cox regression analyses of survival

From: The prognostic role of plasma fibrinogen in adult secondary hemophagocytic lymphohistiocytosis

Characteristics

Unadjusted

Adjusted

HR (95% CI)

P

HR (95% CI)

P

Male

0.85 (0.75–0.96)

0.010

  

Age, years

1.00 (0.99–1.00)

0.009

1.00 (0.99–1.00)

0.017

ANC > 1.0 × 109/L

0.94 (0.84–1.06)

0.331

  

HB < 90 g/L

0.87 (0.77–0.98)

0.027

  

PLT < 100 × 109/L

0.76 (0.62–0.91)

0.004

0.81 (0.66–0.99)

0.043

LDH ≥ 2.5 × ULN

1.14 (0.93–1.39)

0.205

  

TG ≥ 3.0 mmol/L

0.93 (0.82–1.05)

0.245

  

Fever, ≥ 39.1 °C

1.02 (0.90–1.15)

0.775

  

Splenomegaly

0.95 (0.78–1.16)

0.636

  

Hemophagocytosis

1.08 (0.9–1.29)

0.403

  

Log10 (Ferritin)

0.75 (0.66–0.85)

< 0.001

0.78 (0.68–0.90)

0.001

Log10 (sCD25)

0.77 (0.65–0.92)

0.003

  

EBV infection

0.78 (0.69–0.88)

< 0.001

0.85 (0.74–0.96)

0.011

MHLH

0.78 (0.69–0.88)

< 0.001

0.63 (0.54–0.74)

< 0.001

Treatment

 Support treatment

1.00 (Ref.)

 

1.00 (Ref.)

 

 GC + IVIG

0.90 (0.73–1.11)

0.323

1.08 (0.87–1.35)

0.462

 Chem ± HLH94

1.15 (0.93–1.40)

0.196

1.74 (1.38–2.22)

< 0.001

FIB(g/L)

 3 st tertile

1.00 (Ref.)

 

1.00 (Ref.)

 

 2 st tertile

1.03 (0.88–1.20)

0.726

1.06 (0.90–1.24)

0.486

 1 st tertile

0.76 (0.66–0.87)

< 0.001

0.84 (0.71–0.98)

0.025

  1. Italics indicate statistical significance (P < 0.05)
  2. ANC absolute neutrophil count, HB hemoglobin, PLT platelet, LDH lactate dehydrogenase, TG triglyceride, sCD25 soluble interleukin-2 receptor, EBV Epstein-Barr virus, MHLH malignancy-associated haemophagocytic lymphohistiocytosis, GC glucocorticoid, IVIg intravenous immunoglobulins, FIB fibrinogen, HR hazard ratio, CI confidence interval
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172