Chest MRI to diagnose early diaphragmatic weakness in Pompe disease

Table 3 Correlation between MRI outcomes and pulmonary function tests outcomes

	FVC upright	FVC supine	Δ FVC	MIP	MEP
Thorax-related outcomes
Cranial-caudal ratio	0.518***	0.680***	−0.654***	0.435**	0.187
Anterior–posterior ratio	0.035	0.097	−0.112	−0.008	0.040
Lung area ratio	0.473***	0.636***	−0.610***	0.398**	0.151
CC-AP ratio	0.509***	0.643***	−0.608***	0.403**	0.161
Diaphragm-related outcomes
Diaphragm area ratio	−0.556***	−0.588***	0.484***	−0.355**	−0.293*
Diaphragm height ratio	−0.538***	−0.608***	0.552***	−0.382**	−0.270
Anterior displacement	0.089	0.201	−0.234	−0.065	−0.042
Posterior displacement	0.486***	0.650***	−0.598***	0.322*	0.021

Spearman correlation coefficients between thorax-related outcomes and diaphragm-related outcomes (ratios between end-inspiration and end-expiration outcomes) and outcomes of pulmonary function tests (% predicted). Significant correlations are indicated with *p < 0.05, **p < 0.01 or ***p < 0.001
CC-AP ratio = cranial caudal ratio / anterior posterior ratio. FVC = forced vital capacity, Δ FVC = FVC upright—FVC supine, MEP = mean expiratory pressure, MIP = mean inspiratory pressure

ISSN: 1750-1172