Fig. 1From: A new UHPLC-MS/MS method for the screening of urinary oligosaccharides expands the detection of storage disordersChromatographic profiles of the examined storage disordes and of the internal standard (IS). The characteristic MRM transitions, in positive (+) and negative (−) modes, for each disorder are marked with different colours. Panel A: (1) extract ion chromatogram (XIC) of the seven positive MRM transitions characteristic for the IS maltoheptaose Glc7; (2) XIC of the seven negative MRM transitions characteristic for Glc7; (3) XIC of the three negative MRM transitions characteristic for sialidosis; (4) XIC of the eight positive MRM transitions characteristic for α-mannosidosis; (5) XIC of the nine positive MRM transitions characteristic for β-mannosidosis; (6) XIC of the eight negative MRM transitions characteristic for β-mannosidosis. Panel B: (7) XIC of the six positive MRM transitions characteristic for fucosidosis; (8) XIC of the two negative MRM transitions characteristic for Pompe disease, Vici syndrome, Yunis-Varon syndrome, and Danon disease; (9) XIC of the five positive MRM transitions characteristic for aspartylglucosaminuria; (10) XIC of the ten negative MRM transitions characteristic for aspartylglucosaminuria; (11) XIC of the five positive MRM transitions characteristic for GM1 gangliosidosis; (12) XIC of the seven positive MRM transitions characteristic for GM2 gangliosidosisBack to article page