Fig. 2

ROC curves for the four morphological parameters. a ROC curves were drawn for nuclear area (solid black line, AUROC = 0.689, 95% confidence interval (CI) 0.668–0.710, p < 0.001), perimeter (dotted black line, AUROC = 0.695, 95% CI 0.674–0.716, p < 0.001), radius ratio (solid gray line, AUROC = 0.607, 95% CI 0.585–0.629, p < 0.001), and roundness (dotted gray line, AUROC = 0.619, 95% CI 0.598–0.640, p < 0.001). b ROC curves were drawn for the fraction of lymphocytes with small nuclei (solid black line, AUROC = 0.824, 95% CI 0.717–0.932, p < 0.001), short nuclear perimeters (dotted black line, AUROC = 0.856, 95% CI 0.749–0.964, p < 0.001), low nuclear radius ratios (solid gray line, AUROC = 0.870, 95% CI 0.775–0.965, p < 0.001), and increased nuclear roundness (dotted gray line, AUROC = 0.871, 95% CI 0.778–0.964, p < 0.001). (c) ROC curves were drawn for the fraction of lymphocytes with small nuclear areas and low radius ratios (solid black line, AUROC = 0.892, 95% CI 0.783–1.000, p < 0.001), with small nuclear areas and increased roundness (dotted black line, AUROC = 0.904, 95% CI 0.819–0.989, p < 0.001), with short nuclear perimeters and low radius ratios (solid gray line, AUROC = 0.894, 95% CI 0.784–1.000, p < 0.001), and with short nuclear perimeters and increased roundness (dotted gray line, AUROC = 0.890, 95% CI 0.790–0.990, p < 0.001). ROC, receiver operating characteristic; AUROC: area under the ROC curve