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Table 1 Cases of COVID-19 in French adults with Prader-Willi syndrome between March 2020 and January 2021

From: Paradoxical low severity of COVID-19 in Prader-Willi syndrome: data from a French survey on 647 patients

Clinical characteristics (n = 38)  
 Age (years) 34.1 ± 11.9 [18–60]
 Gender (%) Female: 22 (58); Male: 16 (42)
 Genetic subtype (%) Deletion: 20 (53); UPD: 16 (42); ICD: 1 (3); unknown:1
 Body Mass Index (kg/m2) 40.6 ± 12.7 [21.5–72.5]
 Obesity (BMI ≥ 30 kg/m2) (%) 31 (82)
 Severe obesity (BMI ≥ 35 kg/m2) (%) 21 (55)
 Massive obesity (BMI ≥ 40 kg/m2) (%) 16 (42)
 Type 2 diabetes (%) 12 (32)
 Type 1 diabetes (%) 2 (5)
 Hypertension (%) 14 (37)
 Treated apnea syndrome with nocturnal CPAP (%) 13 (34)
 Respiratory and/or cardiac failure (%) 6 (16)
 Past venous thrombotic events (%) 5 (13)
Living situation at the time of COVID-19 (%)  
 Residential group home 19 (50)
 Living home with family 8 (21)
 Hospital 10 (including 9 from cluster in Hendaye Hospital)
Treatments at the time of COVID-19 (%)  
 Hormones GH: 4 (11); Thyroxine: 16 (42); SHT: 14 (37); HC: 1 (3)
 Antidiabetic treatment 14 (37)
 Antihypertensive treatment 14 (37)
 Lipid lowering therapy 4 (11)
 Vitamin D 23 (61)
 Topiramate 9 (24)
 Antidepressants 12 (32)
 Antipsychotics 21 (55)
 Anxiolytics 9 (24)
COVID-19 diagnosis (%)  
 Positive SARS-CoV-2 RT-PCR test 29 (76)
 Positive IgG against SARS-CoV-2 after infection 9 (24)
 Plaints or clinical signs (%) 24 (63)
 Asthenia 10 (26)
 Fever 15 (39)
 Cough 7 (18)
 Shortness of breath 6 (16)
 Headache 4 (11)
 Diarrhea 3 (8)
 Anosmia 1 (3)
 No clinical sign or plaints 14 (37)
Evolution of symptomatic patients (%)  
 Admitted to hospital 12 (including 9 from cluster in Hendaye Hospital)
 Admitted to ICU 0
 Death 0
 Complete recovery 24 (100)
 Time to complete recovery (days) 6.1 ± 4.4 [1–21]
  1. Results are expressed as mean ± SD [range] for continuous variables and as number (percentage) for categorical variables
  2. BMI body mass index, UPD uniparental disomy, ICD imprinting center defect, GH growth hormone, SHT sex hormone therapy, HC Hydrocortisone, CPAP continuous positive airway pressure, RT-PCR Reverse Transcriptase Polymerase Chain Reaction, IgG immunoglobulins G. ICU intensive Care Unit