Fig. 1

Disease-monitoring algorithm. ^aQuestionnaire to be performed prior to consultation. ^bAdditional test. 6MWT 6-min walk test, ACV abnormal conjunctival vessel, cMRI cardiac magnetic resonance imaging, COMPASS-31 Composite Autonomic Symptom Score-31, DPD ^99mTc-3,3-diphosphono-1,2-propanodicarboxylicacid, ECG electrocardiogram, eGFR estimated glomerular filtration rate, HRDB heart rate deep breathing, KCCQ Kansas City Cardiac Questionnaire, KCS keratoconjunctivitis sicca, mBMI modified body mass index, NCS nerve conduction study, Norfolk QOL-DN Norfolk Quality of Life-Diabetic Neuropathy, NT-proBNP N-terminal prohormone of brain-type natriuretic peptide, OH orthostatic hypotension, OLT orthotopic liver transplantation, PND polyneuropathy disability, PYP ^99mTc-pyrophosphate, QOL quality of life, R-ODS Rasch-built Overall Disability Scale, SF-36 36-item Short-Form Healthy Survey, SFN-SIQ small-fiber neuropathy and symptom inventory questionnaire