Table 1 Characteristics of patients with ATTRv amyloidosis: examples from the published literature
Variable | Japan | Brazil | Portugal | Sweden (Norrbotten) | Spain (Majorca) | Greece (outside Crete) | Italy (Lazio) | France | US (Minnesota) | China | Taiwan | Singapore |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Male sex, % | 65.3 | 52.5 | 56.0 | 68.8 | 50.7 | 66.7 | 63.0 | 61.7 | 79.3 | 77.8 | 69.6 | 58.6 |
Early-onset patients, % | 29.2 | NA | 71.3 | 8.6 | NA | NA | 17.0 | 26.7 | NA | 46.3 | NA | 17.2 |
Late-onset patients, % | 61.2 | NAa | 28.7 | 91.4 | NA | NA | 83.0 | 73.3 | NA | 53.7 | NA | 82.8 |
Median age at onset or diagnosis, years | NA | 32.5 | 38 | 72.8 | NA | NA | NA | NA | 59.6 | NA | NA | 57 |
Mean age at onset or diagnosis, years | NA | NA | 42.8 | 70.4 | 49.8 | 51.1 | NA | NA | NA | 47.8 | 58.2 | NA |
Val30Met mutation, % | 65.0b | 91.9 | NA | 95.7 | 100 | 44.4 | 53.0 | 58.3 | 15.8 | 22.2 | 0 | 13.8 |
Non-Val30Met mutation, % | 34.5b | 8.1 | NA | 4.3 | 0 | 55.6 | 47.0 | 41.7 | 84.2 | 77.8 | 100 | 86.2 |
Positive family history of ATTRv amyloidosis, % | 57.5 | 90.6 | NA | 61.3 | 69.3 | 44.4 | 58.0 | 60.0 | 47.7 | 56.4 | 79.7 | 75.9 |
References | [29] | [30] | [31] | [32] | [33] | [34] | [35] | [36] | [37] | [38] | [39] | [40] |