Study | Method of analysis | Results | |
---|---|---|---|
OR | HR | ||
Spinelli et al. [9] | Univariate Cox analysis with predictor variable thresholds established by ROC curve analysis | NR | Predictors of events*: LVMI (g/h2.7) > 54.3: 1.022 (1.008–1.036), p = 0.002 eGFR ≤ 69: 0.978 (0.961–0.996), p = 0.016 |
Univariate and multivariate Cox regressions | NR | Predictors of events*: eGFR: 0.97 (0.95–0.99), p 0.008 LVMI (g/m2) (univariate): 1.01 (1.00–1.01) p < 0.001 LVMI (g/m2) (multivariate): 1.01 (1.00–1.03) p = 0.03 | |
Univariate and multivariate Cox regressions | NR | HR for 5 g/m2 increase in LVMI 1.1 (1.1–1.2), p < 0.001 (univariate) 1.1 (1.04–1.2), p < 0.001 (multivariate) | |
Multivariate Cox regression analysis | NR | HR for cardiovascular event LVMI (g/h2.7) at baseline (abnormal vs normal*) 1.57 (1.21–2.05) p < 0.001 eGFR at baseline (abnormal vs normal) 1.33 (1.04–1.70) p = 0.021 HR for renal event LVMI (g/h2.7) at baseline (abnormal* vs normal) 1.90 (0.94–3.85) p = 0.074 eGFR at baseline (abnormal* vs normal) 5.88 (2.73–12.68) p < 0.001 * Abnormal LVMI defined as > 50 g/h2.7 in males and > 48 g/m2.7 in females; abnormal eGFR defined as < 90 mL/min/1.73 m2 | |
Lenders et al. [10] | Cox proportional hazards model | NR | Patients without endpoints had an average eGFR at baseline of 102.6 (± 26.6) compared to 71.3 (± 28.1) HR for endpoint-free survival of on ERT patients with an eGFR = < 75 mL/min/1.73 m2: 4.77 (1.93–11.81), p < 0.001 HR for cardiovascular endpoints after ERT initiation endpoint-free survival for patients with an eGFR ≤ 75 mL/min/1.73 m2: 3.59 (1.15–11.18); p = 0.03 |
Univariate and multivariate Cox regressions | NR | HR for occurrence of primary endpoint per SD increase in LVMMI: Crude (2.14, CI 1.52–3.01, p < 0.001), Model 1 (1.65, CI 1.06–2.58, p = 0.03), Model 2 (1.67, CI 1.04–2.73, p = 0.03), Model 3 (1.67, CI 1.04–2.73, p = 0.03) HR for occurrence of primary endpoint per SD increase in eGFR: Crude (0.42, CI 0.28–0.61, p < 0.001), Model 1 (0.45, CI 0.27–0.74, p = 0.002), Model 2 (0.42, CI 0.24–0.74, p = 0.003), Model 3 (0.45, CI 0.25–0.83, p = 0.01) HR for occurrence of primary endpoint for patients with eGFR < 90 mL/min/1.73 m2 at baseline, Crude (6.38 CI 1.91–21.33 p = 0.003) Model 1 (4.3 CI 1.06–17.52 p = 0.04) Model 2 (4.88 CI 1.12–21.24) Model 3 (4.41 CI 0.97–20.06) HR for occurrence of primary endpoint for patients with LVMMI > 107 g/m2 at baseline, Crude (4.28, CI 1.58–11.56 p = 0.004), Model 1 (1.79, CI 0.55–5.82 p = 0.37), Model 2 (1.83, CI 0.56–5.97 p = 0.32), Model 3 (1.75 CI 0.54–5.69 p = 0.35) Higher LVMMI and lower eGFR at baseline associated with a greater risk of developing an adverse clinical event (HR 2.21 [1.43–3.42], p < 0.001 for LVMMI, HR 0.41 [0.27–0.62], p < 0.001 for eGFR) (per SD increase in LVMMI and SD decrease in eGFR)—Excluding atrial fibrillation Crude model contained only LVMMI/eGFR as predictor, Model 1 included age and gender, Model 2: Model 1 + transplant status, dialysis status and Model 3: Model 2 + hypertension status and baseline LVMMI/eGFR | |
Patel et al. [11] | Univariate logistic regression models, eGFR not considered in multivariate model as not selected during stepwise selection | OR of experiencing a CV event for patients with low eGFR (< 60 mL/min/1.73 m2) Men OR: 2.33 (1.22–4.45), p < 0.05 Women OR: 3.85 (1.78–8.32), p < 0.0001 | NR |
Univariate and multivariate Cox regressions | NR | HRs of the additional potential prognostic variables on the clinical event rate, adjusted for age at start of ERT, sex and phenotype Mixed-effect models eGFR (per −10 mL/min/1.73 m2) HR: 1.19 (1.11–1.27), p < 0.001 eGFR < 60 mL/min/1.73 m2 HR: 3.58 (2.21–6.05), p < 0.001 LVMI (per 10 g/m2.7) HR: 1.25 (1.08–1.45), p < 0.01 Multivariate eGFR (per −10 mL/min/1.73 m2) HR: 1.12 (1.03–1.22), p < 0.01 LVMI (per 10 g/m2.7) HR: 1.16 (0.99–1.36), p > 0.05 Multivariate analysis with eGFR as dichotomous variable eGFR (< 60 mL/min/1.73 m2) 2.66, CI 1.45–4.90, p = 0.002 LVMI (per 10 g/m2.7) 1.19, CI 1.02–1.38, p = 0.028 Multivariate analysis, excluding renal events eGFR (per -10 mL/min/1.73 m2) 1.01, CI 0.93–1.10, p = 0.78 LVMI (per 10 g/m2.7) 1.19, CI 1.02–1.38, p = 0.03 |