Variable | Cases (n = 14) | Controls (n = 24) | p-value |
---|---|---|---|
Gender – n (%) |  |  |  |
Males Females | 9 (64) 5 (36) | 17 (71) 7 (29) | p = 0.7281 |
Type of Pull-through – n (%)* |  |  |  |
Retrorectal with pouch Endorectal or Perirectal | 3 (21) 11 (79) | 9 (37.5) 15 (62.5) | p = 0.4722 |
Redo – n (%) | 3 (21) | 7 (29) |  |
Age at enrolment [years] – median (range) | 13.1 (1.5–24.2) | 11.5 (1.7–35) | p = 0.9044 |
Timespan from surgery [years] – median (range) | 11.5 (0.7–21.7) | 9.5 (0.9–26.5) | p = 0.8684 |
Syndromes or associated anomalies – n (%) | 2 (14) | 6 (25) | p = 0.6836 |
Positive familial history for Hirschsprung – n (%)* | 3 (21) | 5 (22) | p = 1.000 |
RET mutations – n (%)* | 3 (30) | 11 (48) | p = 0.1750 |
Positive HAEC status – n (%)* | 8 (57) | 8 (36) | p = 0.1870 |
Median (range) of FC [µg/g] | 485 (16-1710) | 50 (9-1312) | p = 0.0012 |
Positive OFB (%) | 8 (57%) | 3 (12%) | p = 0.0076 |
Questionnaire results – n (%) |  |  |  |
Abdominal pain | 7 (50) | 16 (67) | p = 0.4924 |
Distended abdomen | 4 (29) | 9 (37.5) | p = 0.7281 |
Rectal bleeding | 7 (50) | 5 (21) | p = 0.0812 |
Stools > 5 | 9 (64) | 16 (67) | p = 1.0000 |
Liquid stools | 8 (57) | 10 (42) | p = 0.5030 |
Night-time stools | 11 (79) | 16 (67) | p = 0.4882 |
Limitation of daily activities | 8 (57) | 9 (38) | p = 0.3176 |
Dietary limitations | 10 (71) | 12 (50) | p = 0.3087 |
Iron supplementation | 5 (36) | 5 (24) | p = 0.4485 |
Blood transfusion | 3 (21) | 0 (0) | p = 0.0431 |
Antibiotic administration | 3 (21) | 3 (13) | p = 0.6497 |
Anti-inflammatory drugs | 1 (7) | 1 (4) | p = 1.0000 |