Table 2 Laboratory data of 22 HHT-patients and 20 healthy controls

Platelet count, 10⁹/L

F: 145–350; M:165–400

254

(IQR 230–287)

288

(IQR 250–381)

Mean platelet volume, fL (SD)

6–11

9.5

(IQR 9.1–10.4)

9.6

(IQR 9.2–10.0)

Immature platelet fraction, %

0.011–0.061

0.025

(IQR 0.016–0.041)

0.027

(IQR 0.018–0.035)

Fibrinogen µmol/L

5.5–11.5

8.7 (± 1.6)

9.9 (± 1.6)

D-dimer, mg/L FEU

0-55y: < 0.5; 55–65y: ≤ 0.6; 65–75y: ≤ 0.7; 75–85y: ≤ 0.8

85–95y: ≤ 0.9

0.20

(IQR 0.19–0.34)

0.37

(IQR 0.19–0.53)

INR (factor II + VII + X)

0.9–1.1

1.0

(IQR 1–1.01)

1.0

(IQR 1–1.05)

APTT, seconds

27–40

24 (± 1)

24 (± 2)

Folate, nmol/L

 > 7

13.5

(IQR 11–20)

15.0

(IQR 9–29)

Haemoglobin, mmol/L

F: 7.3–9.5, M: 8.3–10.5

8.8 (± 0.8)

7.2 (± 1.5)

MCV, fL

85–100

88.5

(IQR 85–91)

86

(IQR 81–93)

Reticulocytes, 10⁹/L

F: 29–103, M:32–112

65

(IQR 51–80)

84

(IQR 73–118)

MCHC, mmol/L

19.7–22.2

21.2

(IQR 21.1–21.6)

20.3

(IQR 19.4–21.0)

Iron, µmol/L

9–34

20

(IQR 14–24.5)

8

(IQR 5–12.5)

Ferritin, µg/L

F: 15–180, M: 15–560

73.5

(IQR 47–123)

37.5

(IQR 22–68)

Transferrin, µmol/L

25–45

33

(IQR 31–35)

37

(IQR 32–40)

Transferrin saturation, %

F: 0.1–0.5, M:0.15–0.57

0.29

(IQR 0.2–0.37)

0.11

IQR (0.05–0.18)

White blood cell count, 10⁹/L

3.5–8.8

5.8 (± 1.1)

5.8 (± 1.8)

Creatinine, µmol/L

F: 45–90, M: 60–105

69

(IQR 64–78)

72

(IQR 66–83)

Albumin, g/L

15–40 y: 36–50, 40–70 y: 36–48, ≥ 70 y: 34–45

48

(IQR 46–50)

45

(IQR 43–47)

Alanine aminotransferase, U/L

F: 10–45, M: 10–70

24

(IQR 19–31)

22

(IQR 19–28)

Gamma-glutamyl transferase, U/L

F: 18-40y:10–45, > 40y: 10–75, M: < 40: 10–80, > 40: 15–115

16.5

(IQR 13–20.5)

29.0

(IQR 18–56)

Alkaline phosphatase, U/L

35–105

65

(IQR 56–71)

83

(IQR 65–90)

Bilirubin, µmol/L

5–25

8

(IQR 7.8–11)

6

(IQR 4–9.3)

Potassium, mmol/L

3.5–4.4

3.9 (± 0.2)

4.0 (± 0.35)

Sodium, mmol/L

137–145

139.6 (± 1.6)

139.1 (± 2.5)

Calcium ionized, mmol/L

1.18–1.32

1.3 (± 0.03)

1.2 (± 0.05)

Lactate dehydrogenase, U/L

 < 70y: 105–205, > 70y: 115–255

189 (± 24)

192 (± 32)

Cobalamin, pmol/L

200–600

288

(IQR 253–317)

281

(IQR 240–424)