Table 1 Demographic characteristics and basic biochemical features of PHP1, normal control and PHPT group
PHP1 (n = 49) | Normal control (n = 30) | PHPT (n = 64) | p1 | p2 | p3 | |
|---|---|---|---|---|---|---|
M/F (n/n) | 26/23 | 14/16 | 13/51 | 0.818 | 0.014 | 0.001 |
Age (years) | 25.1 ± 10.8 | 26.3 ± 11.2 | 55.5 ± 14.3 | 0.658 | < 0.001 | < 0.001 |
< 18 yo [n, (%)] | 11 (22.4%) | 9 (30%) | 0 (0%) | 1.000 | 0.004 | 0.001 |
≥ 18 yo [n, (%)] | 38 (77.5%) | 21 (70%) | 64 (100%) | |||
BMI (kg/m2) | 23.88 ± 5.23 | 21.72 ± 3.07 | 23.88 (19.47–32.24) | 0.117 | 0.004 | 0.308 |
Overweight [n, (%)] | 11 (22.4%) | 6 (20%) | 25 (29.1%) | 0.130 | – | – |
Obese [n, (%)] | 7 (14.3%) | 0 (0%) | 16 (18.6%) | |||
Overweight/obese [n, (%)] | 18 (36.7%) | 6 (20%) | 41 (64.1%) | 0.207 | < 0.001 | 0.004 |
Ca (mmol/L) | 2.24 (1.43–2.50) | 2.42 ± 0.07 | 2.78 ± 0.18 | 0.048 | < 0.001 | < 0.001 |
P (mmol/L) | 1.53 ± 0.37 | 1.19 ± 0.14 | 0.87 (0.45–1.20) | 0.002 | < 0.001 | < 0.001 |
ALP (U/L) | 76.0 (37.0–443.0) | 58.2 ± 15.3 | 102.0 (54.0–673.0) | < 0.001 | < 0.001 | < 0.001 |
24hUCa (mmol) | 1.69 (0.10–7.90,n = 42) | NA | 7.48 ± 3.13 | – | – | < 0.001 |
β-CTX (ng/ml) | 0.34 (0.08–2.90) | 0.12 (0.07–0.34) | 0.74 (0.05–3.22) | < 0.001 | < 0.001 | 0.108 |
25OHD (ng/ml) | 30.95 (10.30–136.90) | 19.16 ± 10.27 | 17.69 ± 8.98 | 0.003 | 1.000 | < 0.001 |
TP1NP (ng/ml) | 54.0 (23.9–1141.0) | 56.7 (23.8–99.3) | 67.7 (13.1–651.1) | 0.420 | 0.126 | 0.553 |
PTH (pg/ml) | 138.20(10.0–630.3) | 37.78 ± 9.58 | 141.85 (55.7–756.7) | < 0.001 | < 0.001 | 0.181 |
Cr (μmol/L) | 67.69 ± 17.63 | 74.30 ± 17.00 | 61.5 (40–134) | 0.531 | 0.024 | 0.129 |
Alb (g/L) | 47(31–53) | 46.00 ± 2.27 | 45.23 ± 2.73 | 0.325 | 0.184 | 0.022 |
ALT (U/L) | 16 (7–68) | 20.83 ± 9.61 | 17 (7–102) | 0.141 | 1.000 | 0.022 |