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Fig. 5 | Orphanet Journal of Rare Diseases

Fig. 5

From: Tracheal agenesis versus tracheal atresia: anatomical conditions, pathomechanisms and causes with a possible link to a novel MAPK11 variant in one case

Fig. 5

Structural analysis of the implications of Met109Leu substitution in MAPK11. The ATP binding site of MAPK11 with sulphur atom Sδ of Met109 marked in dark yellow (left) which is absent after a substitution Met109Leu (right). The crystalline structure of MAPK11 (PDB ID: 3GP0) was analyzed using the PyMOL software (A). Schematic representation of the structural differences between the methionine and leucine side chains. The sulphur atom Sδ of methionine along with its two electron ion pairs is highlighted in a dark yellow rectangle (B)

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172