Fig. 4
Moderate-severe impact of clinical events, signs and symptoms in adults, adolescents and children with OIa. OI, osteogenesis imperfecta. aQuestions 114, 116, 118–131, 133–142, 188, 191, 193, 194, 195, 197–215, 319, 321, 323, 324, 325, 327–345 “In the past 12 months, how has x impacted your life”, where x is any clinical sign, symptom or event participants reported to have experienced in the past 12 month in questions 113, 187, 251–253. These follow up questions were unavailable for caregivers who provided information on multiple care recipients. Respondents chose a single answer option from a 5-level Likert scale “Not at all impacted–Severely impacted” and I don’t know, prefer not to say. The prevalence of gynaecological problems was calculated within the female subpopulations (n = 1008, n = 51 and n = 137, respectively)