Fig. 1
From: Minimal clinically important differences in six-minute walking distance in late-onset Pompe disease
Anchor-based MCIDs for 6MWD (% predicted) for subgroups of patients with baseline 6MWD < 150 m, < 300 m, < 400 m, < 450 m, and ≥ 450 m. Abbreviations: 6MWD 6-min walk distance, m meter, FVC forced vital capacity, FVC ≥ 3% MCID based on patients with an FVC (% predicted) change from baseline of ≥ 3% at Week 52, MCID minimal clinically important difference, PROMIS Patient-Reported Outcome Measures Information System, PROMIS ≥ 0 MCID based on patients with a PROMIS Physical Function short form 20a (PF) change from baseline of ≥ 0 points at Week 52, PROMIS ≥ 2 MCID based on patients with a PROMIS PF change from baseline of ≥ 2 points at Week 52, PROMIS ≥ 4 MCID based on patients with a PROMIS PF change from baseline of ≥ 4 points at Week 52, SGIC Subject’s Global Impression of Change, SGIC ≥ 4 MCID based on patients with an SGIC of ≥ 4 points at Week 52, SGIC ≥ 5 MCID based on patients with an SGIC of ≥ 5 points at Week 52, SGIC = 4 MCID based on patients with an SGIC of = 4 points at Week 52, SGIC = 5 MCID based on patients with an SGIC of = 5 points